A labelled comparison. IN Eternity Clinic does not offer Linerase. Dr Sin Yong explains what it is, what the evidence shows and which skin boosters are used here instead.
WhatsApp to Enquire →Key facts ↓Linerase is an injectable collagen that its maker describes as a freeze-dried type I collagen from horses, mixed with sterile fluid before injection. It supplies collagen to the skin, whereas most skin boosters hydrate, support repair or prompt the skin to make its own. Independent evidence for Linerase is limited. IN Eternity Clinic does not offer it; skin boosters such as Profhilo, Rejuran and Juvelook are used instead.
Linerase is an injectable collagen product from Italy. Its manufacturer describes it as a freeze-dried (lyophilised) powder of type I collagen of equine (horse) origin, which is mixed with sterile fluid just before it is injected. In Singapore it is usually promoted as a “collagen injection” for fine lines, crepey skin, the under-eye area, the neck and the backs of the hands, given as a course of small injections into the skin.
The appeal is easy to understand. Collagen is the protein people associate with firm, young skin, and the idea of putting it straight back where it has been lost sounds direct. The more useful question is what injected collagen actually does once it is in the skin, and how that compares with the skin boosters that hydrate, repair or prompt the skin to make collagen itself.
Skin collagen falls steadily from early adulthood. Older fibroblasts, the cells that make collagen, produce less, and in sun-exposed skin ultraviolet light switches on enzymes that break existing collagen down. Every injectable for skin quality tries to answer that loss in one of four ways:
These are not interchangeable. A product that hydrates will not thicken skin the way a stimulator can, and a stimulator placed in thin under-eye skin carries its own risks. Matching the mechanism to the problem matters more than the brand. Injections that stimulate your own collagen are compared in collagen injection in Singapore.
| What it is | How it is meant to work | Typical course | At IN Eternity Clinic | |
|---|---|---|---|---|
| Linerase | Equine type I collagen, freeze-dried, reconstituted before injection (as described by its maker) | Supplies collagen to the dermis as a scaffold that is remodelled | A course of sessions | Not offered |
| Profhilo | High- and low-molecular-weight hyaluronic acid | Hydration and support of fibroblasts; spreads through the skin | Usually two sessions a month apart | Offered |
| Skinvive | Hyaluronic acid microdroplets | Hydration and smoothness | One session, with review | Offered |
| Rejuran / Plinest | Polynucleotides | Support of repair and skin quality | A course of sessions | Offered |
| Juvelook | Poly-D,L-lactic acid (PDLLA) with hyaluronic acid | Stimulates new collagen over months | A short course | Offered |
| Sculptra | Poly-L-lactic acid (PLLA) | Stimulates new collagen and volume over months | A short course | Offered |
The full range of skin boosters at the clinic, and how they differ, is on skin boosters in Singapore. The difference between boosters, fillers and stimulators is explained in filler vs biostimulator vs skin booster.
“Injecting collagen and making collagen are different promises. Ask which one a product makes, and what evidence stands behind it.”
Injectable collagen is not new. Bovine (cow) collagen implants were among the first injectable fillers, used widely before hyaluronic acid replaced them. Large clinical series from that era found that a small proportion of people developed allergic reactions, which is why skin testing before treatment became standard for those products. The lesson carried forward is simple: animal-derived collagen is a foreign protein, and the immune system can respond to it.
Published clinical evidence specific to Linerase is limited, and much of what is available comes from the manufacturer or small series. That does not mean it has no effect; it means the size, duration and consistency of the effect are not well documented in independent trials. By comparison, hyaluronic acid boosters and polynucleotides have a larger body of published work, including open-label studies of skin quality and consensus reports on their use, though these too are mostly small and short.
A fair way to judge any skin-quality injectable is to ask three things: what exactly is in the vial and where it comes from, what independent evidence supports it, and how its risks are managed.
People who ask about Linerase usually want one of three things: smoother fine lines and crepey texture, better skin around the eyes, or firmer skin on the neck. IN Eternity Clinic does not offer Linerase. For those goals, Dr Sin Yong considers:
Which one fits depends on whether the main issue is dryness, thinning, laxity or volume. Many plans combine a booster with sun protection and a retinoid at home, which protect whatever collagen the treatment builds.
General clinical observations used at consultation; they describe what is checked, not any individual result.
Any injection into the skin can cause redness, swelling, small bumps and bruising for a few days. With an animal-derived collagen there is the additional question of allergy, so it is reasonable to ask whether a test or observation period is advised and what you would do if a reaction appeared. People with a history of allergy to collagen or to the product’s components, or with active autoimmune disease, need a doctor’s view before any such treatment.
Around the eyes, skin is thin and close to important vessels. Thin, superficial boosters carry a low risk, but technique and anatomy knowledge still matter. Injectable treatments are usually deferred in pregnancy and breastfeeding, during active skin infection or cold sores, and close to major dental work.
Most crepey texture is age and sun. A few causes look similar but need a diagnosis first.
Where any of these apply, the cause is settled before any skin-quality treatment.
Cost depends on the product, the amount used, the number of sessions in the course and the areas treated; under-eye, face and neck plans differ. Boosters are usually given as a short course with maintenance, so the total over a year matters more than one session. At IN Eternity Clinic, Dr Sin Yong recommends a product and plan after assessment and gives a written quote before treatment. The consultation fee is S$120, waived with any medical treatment.
No. Linerase is described on this page for comparison. For the same goals the clinic offers skin boosters such as Profhilo, Skinvive, Rejuran and Plinest, and collagen stimulators such as Juvelook and Sculptra, chosen after assessment.
Its manufacturer describes it as a freeze-dried type I collagen of equine (horse) origin, mixed with sterile fluid before injection. Because it is animal-derived, allergy history is relevant before any treatment.
It is often marketed alongside skin boosters, but it works differently. Linerase supplies collagen to the dermis; most skin boosters hydrate the skin or support repair, and collagen stimulators prompt the skin to make its own collagen.
No. Sculptra (PLLA) and Juvelook (PDLLA) contain no collagen; they are collagen stimulators that prompt the skin to make new collagen over months. Linerase is collagen itself, supplied from an animal source.
Injectable collagen has been used for decades. Older bovine collagen fillers caused allergic reactions in a small proportion of people, which is why skin testing became standard for them. Ask what is in the product, its source and how reactions are handled.
Options include polynucleotide boosters such as Rejuran Eye or Plinest, careful hyaluronic acid treatment, and tightening where laxity is part of the picture. The choice depends on whether lines, hollowing, pigment or puffiness is the main issue.
It varies with the product and the skin. Hydrating boosters are usually maintained every few months to a year; collagen stimulators build over months and last longer. Sunscreen and home care help any result hold.
Usually small bumps, redness or bruising for one to a few days. Make-up can often be worn the next day. Strenuous exercise, saunas and facial massage are avoided for a day or two.
IN Eternity Clinic, 9 Scotts Road, #12-01 Pacific Plaza, Singapore 228210. By appointment with Medical Director Dr Sin Yong. Monday to Saturday, 11am to 8pm. WhatsApp or call +65 8815 3008. The consultation fee is waived with any medical treatment.
These sources describe mechanisms and general evidence. They are not a promise of any individual result; suitability is decided at an in-person assessment.