Woman with calm, fine-textured skin representing skin repair

Plinest · Polynucleotides · PN Skin Booster · Orchard Road

Plinest Singapore

Name: Plinest Singapore — Polynucleotide Booster | IN Eternity Clinic
Creator: Dr Sin Yong
Published: 2026-10-07

Support for skin that has worn thin.

Plinest is a polynucleotide injectable aimed at the repair and resilience of thin, tired skin. This guide explains how it works. IN Eternity Clinic on Orchard Road offers Plinest, and Dr Sin Yong advises at assessment whether a polynucleotide suits you.

WhatsApp to Enquire →Key facts ↓

Polynucleotides

Repair

Skin quality aim

Eye version

For thin periorbital skin

Course

Of sessions

Key facts

What it is: a sterile gel of long-chain polynucleotides purified from fish DNA, made by Mastelli in Italy.
PN and PDRN: both come from DNA; polynucleotides are longer chains that form a viscous gel, while PDRN is shorter fragments.
Typical aims: thin, dull or crepey skin, early fine lines, and skin quality around the eyes and neck.
What it does not do: it does not add volume or change facial shape.
Who needs caution: people with fish allergy, those who are pregnant or breastfeeding, and anyone with active skin infection or inflammation.
Where: IN Eternity Clinic, 9 Scotts Road, #12-01 Pacific Plaza, Singapore.

Reviewed by Dr Sin Yong, Medical Director, IN Eternity Clinic · Last updated 7 October 2026

How it works

What are polynucleotides, and what do they do?

Polynucleotides are chains of nucleotides, the building blocks of DNA, purified from fish sources so that proteins and other contaminants are removed. In the skin they form a hydrating gel and are thought to act as a scaffold and a signal for fibroblasts, supporting the tissue’s own repair processes and collagen production.

The evidence base includes laboratory work, consensus statements from experienced injectors and a growing number of clinical studies, including a small randomised study in acne scarring. It is promising but not yet extensive, and results vary between people. The PDRN explainer covers the related, shorter-chain molecule.

Suitability

Plinest, Rejuran or another booster?

Plinest and Rejuran are both polynucleotide boosters and are often compared; the Plinest vs Rejuran article sets out the differences. Polynucleotides tend to be considered for skin that is thin, sensitised or slow to recover, rather than skin that mainly needs hydration, where a hyaluronic acid booster may suit better.

Around the eyes, thin crepey skin and fine lines are a common reason people ask about PN. Where the problem is a hollow tear trough or puffiness, the cause is different and is covered on tear trough refinement.

Comfort

Does it hurt? Comfort and numbing

Polynucleotide injections are known for stinging more than many other boosters, because the gel is viscous and placed superficially in multiple points. Numbing cream is applied for 30 to 45 minutes beforehand, and treatment is paced with pauses. Around the eyes, very fine injections or a cannula are used.

Most people describe it as uncomfortable but manageable, and the sensation stops when the injections do.

Timeline

What to expect: day by day

Day 0. Small raised bumps at each injection point and some redness. These usually flatten within a few hours to a day.

Days 1–3. Mild swelling and possible pinpoint bruises, especially around the eyes. Makeup after the first day if the skin is intact; avoid saunas and strenuous exercise.

Week 1. Marks fade. Any early glow is mostly hydration.

Weeks 2–4. Polynucleotides are given as a course, so the next session is commonly due within this period.

Review. Skin quality is assessed after the course, typically a few weeks after the last session, before any maintenance is planned.

Safety

Risks and who should not have it

Common effects are redness, swelling, bumps and bruising at the injection points. Less common are prolonged lumps, infection and allergic reactions. Because the product is derived from fish, people with fish allergy need careful assessment and may be advised against it.

Any injectable used in Singapore should be registered with HSA; the HSA registration guide explains how to check. Treatment is not given during pregnancy or breastfeeding, or over active acne, infection or eczema in the area.

Myths and facts

Common myths, answered

Myth: Polynucleotides are the same as “salmon DNA facials”.
Fact: Injected polynucleotides are purified, sterile medical products. Topical serums with DNA-derived ingredients act only on the skin surface.
Myth: Plinest fills lines like a filler.
Fact: It does not add volume. It aims to support skin quality over a course of sessions.
Myth: One session is enough.
Fact: Polynucleotides are given as a course; a single session rarely shows much on its own.
Myth: Fish allergy does not matter for an injection.
Fact: It does. The product is fish-derived, so allergy history is checked before any decision.

Questions

Frequently asked questions

What is Plinest?

Plinest is a polynucleotide skin booster made from highly purified fish DNA fragments. It is injected into the skin to support repair, hydration and thickness in skin that looks thin, tired or crepey. There are variants for the face, the eye area and other uses.

What is the difference between Plinest and Rejuran?

Both are polynucleotide injectables, made by different manufacturers, with differences in formulation, concentration and the range of versions available. In practice both aim to support skin quality and repair rather than add volume. Which, if either, suits you depends on your skin, the area and your history, and is decided at assessment.

How many sessions of Plinest are usually needed?

Polynucleotides are given as a course, commonly three or four sessions spaced a few weeks apart, followed by maintenance if it proves helpful. The exact plan depends on your skin, the area treated and how you respond after the first sessions. A single session on its own rarely shows much.

Can Plinest be used under the eyes?

A version designed for the eye area is used for thin, crepey skin and fine lines around the eyes. It does not fill hollows or remove eye bags, which have different causes such as volume loss or fat. Those are assessed separately and may need a different treatment altogether.

Is Plinest safe if I have a fish allergy?

Fish allergy needs specific discussion because the product is derived from fish DNA. Although it is highly purified, the risk of a reaction cannot be ruled out. Depending on the nature and severity of the allergy, you may be advised not to have it. Tell the doctor about all allergies before treatment.

How much does Plinest cost in Singapore?

Fees depend on the area treated, the amount of product, the version used and the number of sessions in the course. Whether a polynucleotide is the right choice for your skin is decided first, as another booster or treatment may suit better. Fees are then explained at consultation.

References

Cavallini M, Bartoletti E, Maioli L, et al. Consensus report on the use of PN-HPT (polynucleotides highly purified technology) in aesthetic medicine. J Cosmet Dermatol 2021;20(3):922-928. doi:10.1111/jocd.13679
Araco A, Araco F. Preliminary Prospective and Randomized Study of Highly Purified Polynucleotide vs Placebo in Treatment of Moderate to Severe Acne Scars. Aesthet Surg J 2021;41(7):NP866-NP874. doi:10.1093/asj/sjab125
Health Sciences Authority, Singapore. Infosearch — registered medical devices and health products. hsa.gov.sg
Singapore Medical Council. Guidelines on Aesthetic Practices for Doctors (2016 edition). healthprofessionals.gov.sg/smc

These sources describe mechanisms and general evidence. They are not a promise of any individual result; suitability is decided at an in-person assessment.