The needle-free Deep Synergy Skin Booster
The Deep Synergy Booster is a CLASSYS skin-booster ampoule delivered into the skin with ultrasound instead of injections. It is chosen for hydration, a brighter-looking tone and smoother texture, with no puncture marks. Assessed and planned by Medical Director Dr Sin Yong, a CLASSYS Key Opinion Leader.
- 0 needles
- Ultrasound delivery
- Minimal downtime
- Hydrafacial® also available
- Pacific Plaza, Orchard Road
Assessment with Dr Sin Yong · Mon–Sat 11am–8pm · Pacific Plaza, 9 Scotts Road
The short answer
What is the Deep Synergy Booster?
The Deep Synergy Booster is a skin-booster ampoule made by CLASSYS. It is not injected. The ampoule is spread on cleansed skin and delivered with ultrasound, which helps carry it into the skin. The ampoule itself serves as the contact medium, so there is no gel to wipe off. CLASSYS lists glutathione, niacinamide, PDRN, centella asiatica, adenosine, seven hyaluronic acids, ten peptides and seventeen amino acids among its ingredients. It is a skin-quality treatment for hydration, a brighter-looking tone and texture. It is not a filler and not a lift. Unlike injectable skin boosters such as Rejuran (polynucleotides) or Profhilo (hyaluronic acid), it places no product with a needle, so it trades a measured injected dose for comfort and minimal downtime. At IN Eternity Clinic, Dr Sin Yong assesses you first and may pair the Deep Synergy Booster with a Hydrafacial® for surface cleansing, or with a lifting treatment where laxity is also a concern.
What the Deep Synergy Booster is chosen for
Skin that looks tired, dry or dull, without the needles
The Deep Synergy Booster works on skin quality. It suits people who want their skin to look fresher and more hydrated, and people who would not otherwise have a skin booster because they do not want needles.
Dull, uneven-looking skin
The ampoule includes glutathione and niacinamide, which CLASSYS positions for a brighter, more even-looking tone. Changes build over a course.
Dehydrated, tight skin
Seven types of hyaluronic acid, plus arginine and amino acids, target hydration. It is often chosen when skin feels tight and shows fine dehydration lines.
Rough texture and fine lines
Adenosine and peptides are included for smoother-looking texture and fine lines. It is not a treatment for deep folds.
Wanting a booster without injections
Nothing is injected, so there are no puncture marks and none of the needle bruising that can follow injectable boosters.
Before an event
Downtime is minimal, so the Deep Synergy Booster fits when you cannot risk bruising. A Hydrafacial® is also available for a same-day clean glow.
Skin that feels dry or reactive
PDRN and centella asiatica are included for repair and soothing. Ingredients are reviewed with you for allergies before treatment.
Key facts
Ten things worth knowing about the Deep Synergy Booster and other skin boosters
- A CLASSYS ampouleThe Deep Synergy Booster (sold as DSB 357, “The Deep Synergy Booster”) is a skin-booster ampoule made by CLASSYS, the Korean aesthetic-device company.
- No needle at any pointThe ampoule is applied to the skin surface and delivered with ultrasound. Nothing is injected, so there are no puncture marks.
- Delivered with ultrasoundUltrasound energy passed over the ampoule helps carry its ingredients into the skin, an approach known as sonophoresis.
- The ampoule is the contact mediumThe ampoule takes the place of ultrasound gel, so it is not wiped off afterwards. The remaining ampoule is patted into the skin at the end.
- What is in itCLASSYS lists glutathione and niacinamide (tone), PDRN and centella asiatica (repair and soothing), seven hyaluronic acids and arginine (hydration), and adenosine, ten peptides and seventeen amino acids (elasticity and fine lines).
- Principle established; product data from the makerUltrasound can increase skin permeability, a well-studied effect. The penetration data for this ampoule comes from an ex vivo study supplied by CLASSYS, not from independent peer-reviewed clinical trials.
- It works as a courseSkin-quality change builds over a short course of sessions, followed by periodic maintenance. The number of sessions is set at your assessment.
- Skin boosters are not all the sameRejuran and Plinest are polynucleotides (PN, from salmon and trout DNA); Profhilo is high-concentration hyaluronic acid; Juvelook combines PDLLA with hyaluronic acid. They work in different ways and are injected, whereas the Deep Synergy Booster is applied to the skin and delivered with ultrasound.
- “Needle-free” can mean different thingsUltrasound-assisted delivery, needle-free jet injectors and electroporation are all marketed as needle-free. A jet injector still pushes product under the skin; ultrasound delivery does not pierce it.
- Skin quality, not a lift or a fillerThe Deep Synergy Booster improves the look and feel of the skin. It does not add volume and does not treat sagging. Where laxity is the concern, lifting treatments are discussed alongside it.
The Deep Synergy Booster brings skin-quality treatment to people who would never have a needle. But it is not an injection and it is not a lift, and patients should know exactly which one they are buying.
Dr Sin Yong on the panel at the 7th CLASSYS APAC Symposium, Bangkok, 2026, where he received a CLASSYS KOL Award.
Who treats you
Assessed and treated by Medical Director Dr Sin Yong
Dr Sin Yong is an International Key Opinion Leader for CLASSYS, the maker of the Deep Synergy Booster. He received a CLASSYS KOL Award at the 7th CLASSYS APAC Symposium in 2026. He examines your skin and decides whether the Deep Synergy Booster, a Hydrafacial®, an injectable booster or a combination fits best. The number of sessions is explained before you start.
- MBBS, National University of Singapore
- MRCS, Royal College of Surgeons of Edinburgh
- MSc Aesthetic Medicine, University of London
- MSc Practical Dermatology, Cardiff University
International Key Opinion Leader · CLASSYS · HIRONIC · DEKA · ALMA · FOTONA · LUTRONIC
How it works at IN Eternity
From first message to your Deep Synergy Booster session
WhatsApp us
Tell us what you would like to improve. Our team arranges an assessment at Pacific Plaza, Orchard Road.
Skin assessment
Dr Sin Yong checks hydration, tone, texture, pores and laxity, and confirms whether the Deep Synergy Booster suits you or another route fits better.
Your session
Skin is cleansed and the Deep Synergy Booster ampoule applied. Ultrasound is passed over each area, and the remaining ampoule is patted in. A mask or LED can follow.
Course and upkeep
A short course of sessions, then periodic maintenance. Progress is reviewed through the course.
Skin boosters in Singapore compared
Deep Synergy Booster vs Rejuran vs Profhilo vs Juvelook vs Plinest vs Hydrafacial®
These are the skin-quality treatments people in Singapore most often compare. They use different actives and delivery methods, so the right one depends on what your skin needs and whether you want to avoid needles.
| Deep Synergy Booster | Rejuran | Profhilo | Juvelook | Plinest | Hydrafacial® | |
|---|---|---|---|---|---|---|
| What it is | CLASSYS ampoule with glutathione, niacinamide, PDRN, 7 hyaluronic acids, peptides and amino acids | Polynucleotides (PN) from salmon DNA | High-concentration hyaluronic acid (high and low molecular weight) | PDLLA microspheres with hyaluronic acid | Polynucleotides (PN) from trout DNA | Cleanse, exfoliate, extract and infuse serums |
| Maker | CLASSYS (Korea) | PharmaResearch (Korea) | IBSA (Switzerland) | Vaim (Korea) | Mastelli (Italy) | The HydraFacial Company (USA) |
| How it is given | Applied to the skin and delivered with ultrasound | Many small injections into the dermis | A few injection points per side (BAP technique) | Injections; needle-free jet delivery is also studied | Many small injections into the dermis | Vortex tip on the skin surface |
| Main aim | Hydration, brighter-looking tone, texture | Skin repair, texture, fine lines, thin skin | Hydration and skin laxity | Gradual collagen stimulation and texture | Skin repair and quality | Congestion, dullness, pores |
| Needles | No | Yes | Yes | Usually | Yes | No |
| Downtime | Minimal: mild redness at most | Small bumps for 1–3 days; possible bruising | Small bumps at injection points for a day or two; possible bruising | Bumps or redness for 1–3 days; possible bruising | Small bumps for 1–3 days; possible bruising | None |
| Typical course | Short course, then maintenance | Commonly 3 sessions a few weeks apart | Usually 2 sessions about 4 weeks apart | A short course a few weeks apart | A short course a few weeks apart | Monthly or as needed |
| Evidence base | Sonophoresis principle; product data from manufacturer | PN studies (systematic review: low–moderate quality) | Systematic review of Profhilo studies | Clinical studies; smaller evidence base | PN studies (systematic review: low–moderate quality) | Clinical studies of hydradermabrasion |
General comparison for information. Brand names belong to their owners. Suitability, product and number of sessions are decided at your assessment; Rejuran and Profhilo are also available at IN Eternity Clinic.
Head to head
Which skin booster? The comparisons patients ask about
Short, direct answers to the comparisons we are asked about most often in clinic.
Deep Synergy Booster vs Rejuran
Rejuran injects polynucleotides into the dermis for repair and texture, with small bumps for a few days. The Deep Synergy Booster contains PDRN among other actives but is applied to the skin and delivered with ultrasound, with no needles. Rejuran suits a set injected dose; Deep Synergy suits people who want to avoid needles and downtime.
Deep Synergy Booster vs Profhilo
Profhilo injects a high concentration of hyaluronic acid at a few points per side to hydrate and improve laxity, usually over 2 sessions. The Deep Synergy Booster is needle-free and focuses on hydration, tone and texture; it does not deliver an injected hyaluronic acid dose.
Profhilo vs Rejuran
Profhilo is hyaluronic acid for hydration and laxity. Rejuran is polynucleotide for repair and texture. They work differently and are sometimes combined in one plan.
Juvelook vs Rejuran
Juvelook pairs PDLLA, a collagen stimulator that works gradually, with hyaluronic acid. Rejuran uses polynucleotides for repair. One builds collagen over months; the other supports skin repair.
Plinest vs Rejuran
Both are polynucleotide boosters: Plinest from trout DNA (Mastelli, Italy) and Rejuran from salmon DNA (PharmaResearch, Korea). They belong to the same category, with differences in formulation and range.
Deep Synergy Booster vs Hydrafacial®
A Hydrafacial® cleanses, extracts and infuses serums at the surface for a same-day glow. The Deep Synergy Booster uses ultrasound to help an active ampoule into the skin over a course. Many people alternate the two.
Is there a “needleless Rejuran”?
Rejuran as a clinic treatment is injected. Offers of “needleless Rejuran” usually mean a polynucleotide product applied to the skin with a device. If you want a needle-free option, the Deep Synergy Booster is an ampoule designed for ultrasound delivery that includes PDRN.
Rejuran masks and ampoules vs Rejuran injections
Rejuran masks, the Turnover ampoule and the Dual Effect ampoule are home skincare applied to the surface. They are different products from the Rejuran injected in clinic.
Needle-free skin boosters
What “needle-free skin booster” can mean
Several different technologies are sold as needle-free. It helps to know which one you are being offered.
| Method | How it works | Examples | Worth asking |
|---|---|---|---|
| Ultrasound-assisted (sonophoresis) | Ultrasound passed over a topical ampoule increases skin permeability; the skin is not pierced | Deep Synergy Booster at IN Eternity Clinic | Which ampoule is used and what is in it |
| Needle-free jet injection | A pressurised device pushes product through the skin without a needle | Used with some injectable boosters, including PDLLA in published studies | Product still goes under the skin, so marks or bruising are possible |
| Electroporation | Brief electrical pulses are used to increase absorption of a topical serum | Various “no-needle mesotherapy” devices | Evidence differs from device to device |
| Microneedling with serum | Fine needles create micro-channels for a serum; this is not needle-free | Various devices | Expect some redness and pinpoint marks |
| Home ampoules and masks | Skincare applied to the surface, no device | Rejuran skincare and other ampoules | These are skincare, not a clinic treatment |
General information. Dr Sin Yong explains which method is used before any treatment at IN Eternity Clinic.
The treatments
How the Deep Synergy Booster and Hydrafacial® work
Deep Synergy Booster with ultrasound delivery
The ampoule is spread on the skin and ultrasound is passed over it to help its ingredients penetrate. CLASSYS describes the ampoule as made with a patented capsule method (Membrane Emulsification Technology) and free of emulsifiers and pigments. Ingredients are reviewed with you for allergies first.
Hydrafacial®
For congested or dull skin, a Hydrafacial® cleanses, exfoliates, extracts and infuses serums in one sitting with little downtime for most people. It can be used on its own, before an event, or alternated with Deep Synergy Booster sessions.
What to expect
Sessions, comfort and downtime
| Visit length | Deep Synergy Booster: about 30–45 minutes including cleansing. Hydrafacial®: 30–60 minutes |
| Comfort | Deep Synergy Booster: most people find it comfortable, with at most mild warmth. Hydrafacial®: cool, gentle suction |
| Downtime | Deep Synergy Booster: mild, short-lived redness is possible; most people return to normal activities the same day. Hydrafacial®: none |
| Number of sessions | Deep Synergy Booster: a short course, then periodic maintenance. Hydrafacial®: monthly or as needed |
| When results show | Skin often looks fresher soon after a session; tone and texture changes build over the course |
| Aftercare | Sunscreen, gentle skincare, and a short pause on strong actives such as retinoids as advised |
Typical ranges only. Your own plan, number of sessions and cost are set at consultation after assessment.
Suitability & safety
Who the Deep Synergy Booster suits, and when we wait
Usually a good fit
- Dull, dehydrated or tired-looking skin
- Fine lines and rough texture
- People who do not want injections
- Preparation before an event, with no bruising risk
- Skin that feels dry or reactive
Treated with caution or deferred
- Pregnancy (deferred as a precaution)
- Active infection, open wounds or inflamed acne in the area
- Known allergy to an ampoule ingredient (reviewed first)
- Very recent procedures in the area (timing discussed)
- Significant sagging: lifting treatments are discussed instead
Possible effects include temporary redness, warmth or mild sensitivity. Any reaction to an ingredient is uncommon, and the ingredient list is reviewed with you before treatment.
Questions patients ask
Deep Synergy Booster and Hydrafacial FAQ
What is the Deep Synergy Booster?
The Deep Synergy Booster is a CLASSYS skin-booster ampoule. It is applied to the skin and delivered with ultrasound, so no injections are used.
Is the Deep Synergy Booster really needle-free?
Yes. The ampoule is spread on cleansed skin and ultrasound is used to help it penetrate. Nothing is injected at any point.
What is in the Deep Synergy Booster ampoule?
CLASSYS lists glutathione, niacinamide, PDRN (sodium DNA), centella asiatica extract, adenosine, arginine, seven types of hyaluronic acid, ten peptides and seventeen amino acids.
How is it different from an injectable skin booster?
An injectable booster places a measured dose at a chosen depth with a needle. The Deep Synergy Booster avoids needles and puncture marks and relies on ultrasound-assisted delivery. Injectables remain the better choice when a precise dermal dose is needed, and both are available at IN Eternity Clinic.
Is the Deep Synergy Booster better than Rejuran?
Neither is better in general; they do different jobs. Rejuran injects polynucleotides at a set depth for repair and texture. The Deep Synergy Booster is needle-free and suits people who want hydration, tone and texture with minimal downtime. Dr Sin Yong recommends one, the other or both after assessment.
Deep Synergy Booster or Profhilo: which should I choose?
Profhilo is an injected hyaluronic acid for hydration and laxity, usually given as 2 sessions. The Deep Synergy Booster avoids needles and works on hydration, tone and texture. Where laxity is the main concern, an injectable or lifting treatment may be advised instead.
What is the difference between Profhilo and Rejuran?
Profhilo is high-concentration hyaluronic acid injected at a few points per side for hydration and laxity. Rejuran is polynucleotide injected across the area for repair and texture. They are sometimes combined.
What is the difference between Juvelook and Rejuran?
Juvelook combines PDLLA, which stimulates collagen gradually, with hyaluronic acid. Rejuran uses polynucleotides to support skin repair. They work through different mechanisms.
Is there a needleless Rejuran?
Rejuran as a clinic treatment is injected. So-called needleless Rejuran usually means a polynucleotide product applied to the skin with a device. The Deep Synergy Booster is a needle-free ampoule designed for ultrasound delivery that includes PDRN.
Are Rejuran masks and ampoules the same as Rejuran injections?
No. Rejuran masks and ampoules, such as the Turnover ampoule, are home skincare applied to the surface. The Rejuran used in clinic is an injectable product.
How many sessions do I need?
It is usually done as a short course of sessions, followed by periodic maintenance. Dr Sin Yong recommends a plan after assessing your skin.
Does it hurt, and is there downtime?
Most people find it comfortable, with at most mild warmth. Mild redness can follow but usually settles quickly, and most people return to normal activities the same day.
Can it be combined with other treatments?
Yes, where suitable. It can be scheduled alongside a Hydrafacial® or a lifting treatment when both skin quality and laxity are concerns. Dr Sin Yong plans the combination at assessment.
Deep Synergy Booster or Hydrafacial: which should I choose?
A Hydrafacial works on the surface for an immediate clean, hydrated glow and suits congested or dull skin. The Deep Synergy Booster works on hydration, tone and texture over a course, without needles. Many people alternate the two.
How much does the Deep Synergy Booster cost in Singapore?
Cost depends on the areas treated, the number of sessions and whether it is combined with another treatment. IN Eternity Clinic confirms your plan and cost at consultation.
Who performs the treatment?
Every patient is assessed by Medical Director Dr Sin Yong, an International Key Opinion Leader for CLASSYS, who sets the plan for your skin.
Book your assessment
Find out if the Deep Synergy Booster suits your skin
A short assessment with Dr Sin Yong tells you whether the Deep Synergy Booster, a Hydrafacial®, an injectable booster or a combination fits your skin, and how many sessions to expect. WhatsApp us to arrange a time.
WhatsApp +65 8815 3008IN Eternity Clinic · 9 Scotts Road, #12-01 Pacific Plaza, Singapore 228210 · Mon–Sat 11am–8pm · [email protected]
Related at IN Eternity
References
- Polat BE, et al. Ultrasound-mediated transdermal drug delivery: mechanisms, scope, and emerging trends. J Control Release. 2011. PubMed 21238514
- Yi KH, et al. Skin boosters: definitions and varied classifications. Skin Res Technol. 2024. PubMed 38481069
- Lampridou S, et al. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025. PubMed 39645667
- Lim TS, et al. Polynucleotides HPT for Asian skin regeneration and rejuvenation. Clin Cosmet Investig Dermatol. 2024. PubMed 38371328
- Sparavigna A, et al. A systematic review of the efficacy and safety of Profhilo® and Profhilo® Body. Plast Aesthet Nurs. 2026. PubMed 41920062
- Sparavigna A, et al. Efficacy and tolerability of Profhilo® Structura intended to restore lateral cheek fat compartment: an observational pilot study. Health Sci Rep. 2024. PubMed 38260185
- Seo SB, et al. The effective delivery of poly(D,L-lactic acid) (Juvelook) via needle-free injection (CUREJET) for facial rejuvenation. Aesthetic Plast Surg. 2026. PubMed 41389157
- Ghatge AS, et al. The effectiveness of injectable hyaluronic acid in the improvement of the facial skin quality: a systematic review. Clin Cosmet Investig Dermatol. 2023. PubMed 37038447
- Squadrito F, et al. Pharmacological activity and clinical use of PDRN. Front Pharmacol. 2017. PubMed 28491036
- Bissett DL, et al. Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005. PubMed 16029679
- Freedman BM. Hydradermabrasion: an innovative modality for nonablative facial rejuvenation. J Cosmet Dermatol. 2008. PubMed 19146604
Medically reviewed by Dr Sin Yong, MBBS (NUS), MRCS (Edinburgh), MSc Aesthetic Medicine (London), MSc Practical Dermatology (Cardiff) · Last reviewed 28 September 2026. This page is general information and not a substitute for an individual medical assessment. Results vary between individuals.