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Woman in her late 40s with natural lateral cheek and jawline contours
Profhilo Structura · Hybrid Hyaluronic Acid · Lateral Face · Orchard Road

Profhilo Structura Singapore

Same family as Profhilo. Different layer, different job.

Profhilo Structura is placed in the fat layer of the side of the face rather than spread through the skin. This page explains how it differs from Profhilo. IN Eternity Clinic on Orchard Road offers Profhilo Structura, and Dr Sin Yong advises at assessment whether it fits your face.

WhatsApp to Enquire →Key facts ↓
Hybrid HA
High and low molecular weight
Fat layer
Where it is placed
Lateral face
Main area studied
Assessed
Before any plan
Assessed and treated by Dr Sin Yong, Medical Director · MBBS (NUS) · MRCS (Edinburgh) · MSc Aesthetic Medicine (London) · MSc Practical Dermatology (Cardiff) · Designated DEKA Centre of Excellence

Profhilo Structura is a hybrid hyaluronic acid injectable from IBSA, the maker of Profhilo. Instead of spreading through the skin, it is placed with a cannula into the subcutaneous fat at the side of the face, aiming to support tissue that has thinned and slackened with age. It does not lift like threads or shape like filler.

Key facts
  • What it is: a stabilised mixture of high- and low-molecular-weight hyaluronic acid, made by the same thermal process as Profhilo but formulated for a deeper layer.
  • Where it goes: the subcutaneous fat of the lateral face, usually through a cannula from a small number of entry points.
  • The idea: to support the ageing fat layer, which thins and loses structure over time, rather than to add shape.
  • How it differs from Profhilo: Profhilo spreads in the skin from set points to improve hydration and firmness; Structura works deeper, in the fat compartment.
  • Evidence so far: early clinical series and pilot studies; longer and larger studies are still limited.
  • Where: IN Eternity Clinic, 9 Scotts Road, #12-01 Pacific Plaza, Singapore.
Reviewed by Dr Sin Yong, Medical Director, IN Eternity Clinic · Last updated
How it works

Why the fat layer matters in a sagging face

Facial ageing is not only about skin. The fat beneath it is arranged in compartments, and with age some of these thin, lose their internal structure and support the skin above less well. The lateral cheek compartment, in front of the ear, is one of the areas where this shows as early slackness and a softer jaw outline.

Profhilo Structura uses hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid, the same technology as Profhilo, in a formulation designed for this deeper fat layer. Early clinical experience suggests it can improve the look of lateral cheek support, and laboratory work proposes effects on the fat tissue itself. These findings come from small, early studies, and that is how they should be read.

A woman assessing the side of her face in a mirror
Illustrative image. Not a patient of IN Eternity Clinic.
Suitability

Profhilo, Structura or something else?

If the main concern is skin quality, such as dullness, dryness and fine crepiness, standard Profhilo is the more natural starting point. Structura is considered when the side of the face has softened and the jawline is starting to blur, but the change is mild to moderate. The existing Profhilo Structura guide covers the background.

Where there is clear loss of bony or deep support, a structural product or a collagen stimulator may be more appropriate. Where laxity is mainly in the skin and soft tissue, energy-based lifting such as VF Lift – Vertical Facelift on Volnewmer, or Thermage, may be discussed. Advanced sagging with excess skin is not treated by injectables.

“Profhilo improves the skin. Structura is aimed at the fat beneath it. If your concern is skin quality, the deeper product is the wrong tool.”
— Dr Sin Yong, Medical Director, IN Eternity Clinic
Comfort

Does it hurt? Comfort and numbing

A small amount of local anaesthetic is placed at each entry point, so the main sensation is pressure and a dull pushing feeling as the cannula moves under the skin. Most people find it more comfortable than multiple small injections. Numbing cream may also be used.

The procedure itself usually takes around 15 to 20 minutes per session.

Clear gel on silk suggesting a hyaluronic acid injectable
Illustrative image. Not a patient of IN Eternity Clinic.
Timeline

What to expect: day by day

Day 0. Mild swelling at the sides of the face and small marks at the entry points. You can usually return to normal activities the same day.

Days 1–3. Swelling settles; some tenderness on pressure and occasional bruising at the entry points. Avoid saunas, intense exercise and facial massage.

Week 1. The early fullness from the gel and fluid fades. The face should look like you, not heavier.

Weeks 2–4. Change, if any, develops gradually. Published protocols commonly use a second session around one month after the first.

Review. Photographs in standard positions are compared at review to decide whether a further session is useful.

Safety

Risks to know

Swelling, bruising and tenderness are common and short-lived. Lumps are uncommon because the product spreads within the fat layer, and hyaluronic acid can be broken down with hyaluronidase if needed. Infection and vascular events are rare with cannula technique but remain possible with any injectable, which is why anatomy, sterile preparation and the doctor’s experience matter.

Any product used should be registered in Singapore; the HSA registration guide explains how to check. It is not given during pregnancy or breastfeeding, over active skin infection, or to people allergic to its components.

Myths and facts

Common myths, answered

Questions

Frequently asked questions

What is the difference between Profhilo and Profhilo Structura?

Both use stabilised high- and low-molecular-weight hyaluronic acid. Profhilo is placed in the skin at set points and spreads to improve hydration and firmness. Structura is placed deeper, in the fat of the lateral face, to support tissue that has thinned and softened with age.

Who is Profhilo Structura suitable for?

Generally adults with mild to moderate softening at the sides of the face and early blurring of the jawline, who want a subtle change. It is not suited to advanced sagging with excess skin, or to people whose main concern is skin texture. Suitability is decided in person.

How many sessions are needed?

Published protocols commonly use two sessions about one month apart. The number for you is decided at assessment and reviewed after the first session, since response varies with age, tissue quality and lifestyle. Any further session or maintenance is planned only if the review shows it would help.

Can Profhilo Structura be dissolved?

It is made of hyaluronic acid, so it can be broken down with hyaluronidase, a prescription medicine, if there is a problem such as an unwanted lump. This is one reason it is considered a more adjustable option than collagen stimulators, but it is still placed with care in measured amounts.

Is there downtime?

Most people return to normal activities the same day. Swelling at the sides of the face usually settles within a few days, and bruising at the entry points, if it happens, fades over a week or so. Avoid saunas and intense exercise for a day or two, and plan around important events.

How much does Profhilo Structura cost in Singapore?

Fees depend on the number of syringes, the number of sessions and whether it is combined with other treatments such as energy-based lifting. Whether it is the right choice for your face is decided first, because a different treatment may suit better. Fees are then explained clearly at consultation.

Related at IN Eternity Clinic
Profhilo Structura guideProfhiloProfhilo guideSagging face treatmentProfhilo price guideVF Lift – Vertical Facelift

Book an assessment

IN Eternity Clinic, 9 Scotts Road, #12-01 Pacific Plaza, Singapore 228210. By appointment with Medical Director Dr Sin Yong. Monday to Saturday, 11am to 8pm. WhatsApp or call +65 8815 3008.

WhatsApp to Enquire →Call +65 8815 3008
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Dr Sin Yong
MBBS (NUS) · MRCS (Edinburgh) · MSc Aesthetic Medicine (London) · MSc Practical Dermatology (Cardiff)
International KOL — CLASSYS · HIRONIC · DEKA · ALMA · FOTONA · LUTRONIC
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References

  1. Cassuto D, Cigni C, Bellia G, Schiraldi C. Restoring Adipose Tissue Homeostasis in Response to Aging: Initial Clinical Experience with Profhilo Structura. Gels 2023;9(8):614. doi:10.3390/gels9080614
  2. Sparavigna A, Grimolizzi F, Cigni C, et al. Efficacy and tolerability of Profhilo Structura intended to restore lateral cheek fat compartment: An observational pilot study. Health Sci Rep 2024;7(1):e1743. doi:10.1002/hsr2.1743
  3. Sparavigna A, Tenconi B. Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clin Cosmet Investig Dermatol 2016;9:297-305. doi:10.2147/CCID.S114450
  4. Health Sciences Authority, Singapore. Infosearch — registered medical devices and health products. hsa.gov.sg
  5. Singapore Medical Council. Guidelines on Aesthetic Practices for Doctors (2016 edition). healthprofessionals.gov.sg/smc

These sources describe mechanisms and general evidence. They are not a promise of any individual result; suitability is decided at an in-person assessment.

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